Professor Shoji Takeuchi and former Project Lecturer Koji Sato at the Institute of Industrial Science, the University of Tokyo, have developed a bioinspired electrophysiology technique to record the vapor olfactory response of three-dimensional cell spheroids expressing insect olfactory receptor complexes. Hedonic scale of odor is one of the standard indexes used to evaluate Quality of life (QOL). Olfaction also has important biological roles in insect pathogen vectors throughout their life history. Thus, evaluation of odorants in the environment are important aspects of social life and public health. The olfactory receptors (OR) in the noses of dogs and other animals are sophisticated sensor elements for chemical vapors. Considerable effort has been expended to develop OR-based olfactory sensors. However, the detection of chemical vapors by reconstituted OR proteins has not yet been reported. In this study, the research group expressed insect OR complexes in cell spheroids and arranged them in a hydrogel microchamber array. The spheroids showed olfactory responses to their ligand, which diffused from chemical vapors through the thin surface aqueous layer. Using the same technique, the olfactory responsiveness of a malaria vector mosquito OR were examined. The difference between in vivo and in vitro ligand response suggests that certain compounds
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