Monday 5 May 2014

Mechanobiology: Enzyme micropump autonomously delivers insulin in response to glucose levels

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At catalase enzyme is immobilized on a gold platform. The enzyme pumps out fluid (which contains tracer particles to allow for observation) at a rate that is dependent on the concentration of glucose oxidase and glucose in the surrounding solution. Credit: Sengupta, et al. ©2014 Nature For next-generation smart devices, autonomy is key. These devices will be able to power themselves, independently respond to stimuli, and perform different kinds of work, all without human intervention. With these abilities, smart devices could potentially have very wide-reaching implications.   In a recent study published in Nature Chemistry, Samudra Sengupta, et al., from The Pennsylvania State University, the Ural Branch of the Russian Academy of Sciences, and the University of Puerto Rico-Mayagüez, have designed and demonstrated a self-powered enzyme micropump that autonomously delivers small molecules and proteins in response to specific chemical stimuli. “We demonstrate that surface-anchored enzymes can act as pumps in the presence of their respective substrates, pumping fluid and particles in a directional manner,” coauthor Ayusman Sen, Professor of Chemistry at Penn State, told Phys.org. “This discovery enables the design of non-mechanical, self-powered nano/microscale pumps that precisely control flow rate and turn on in response to specific stimuli. One example described in the paper is

The post Mechanobiology: Enzyme micropump autonomously delivers insulin in response to glucose levels has been published on Technology Org.

 
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